Inhibition of Phosphatidic Acid Biosynthesis bycis-9,10-Methylene Hexadecanoic Acid
نویسندگان
چکیده
منابع مشابه
cis-9,10-Methylene hexadecanoic acid from the phospholipids of Escherichia coli.
Hofmann and Lucas (1) discovered a saturated cyclopropane compound in Lactobadlus arabinosus which they termed lactobacillic acid. Lactobacillic acid was found to be &s-11,12methylene octadecanoic acid (2). A survey by Hofmann et al. disclosed that lactobacillic acid is present in several lactic acid bacteria (3) but absent in a group C streptococcus (4). Lactobacillic acid was also found to be...
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Regulation of membrane lipid biosynthesis is critical for cell function. We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stimulates net phosphatidylcholine (PC) biosynthesis and proliferation of the endoplasmic reticulum (ER) in Arabidopsis thaliana. Here, we show that this response is caused specifically by a reduction in the catalytic activity of ...
متن کاملBiosynthesis of phosphatidic acid, lysophosphatidic acid, diglyceride, and triglyceride by fatty acyltransferase pathways in Escherichia coli.
Fatty acyl coenzyme A-glycerol 3-phosphate, fatty acyl coenzyme A-lysophosphatidic acid, fatty acyl coenzyme A-monoglyceride, and fatty acyl coenzyme A-diglyceride acyltransferase activities were found in a particulate fraction of broken cell preparations of Escherichiu coli. The synthesis of phosphatidic acid and lysophosphatidic acid catalyzed by these enzymes was demonstrated to be dependent...
متن کاملBiosynthesis of phosphatidic acid from lysophosphatidic acid and palmityl coenzyme A.
In the preceding paper evidence was presented for the biosynthesis of lysophosphatidic acid from monoglyceride and adenosine triphosphate (1). Exogenous monoglycende was found to stim.ulate the formation of phosphatidic acid as well as lysophosphatidic acid. This observation suggested that lysophosphatidic acid was being converted to phosphatidic acid and therefore was functioning as an interme...
متن کاملThe Biosynthesis of Phosphatidic Acid and Lysophosphatidic Acid by Glyceride Phosphokinase Pathways in Escherichia Coli.
Phosphatidic acid has been given a key position in the scheme of animal lipid metabolism because of its ability to serve as a presursor of a variety of animal lipids. The recent reports of the biosynthesis of phosphatidylserine and phosphatidylglycerol (1, 2) in Escherichia coli and other bacteria suggest that phosphatidic acid (in the coenzyme form, cytidine diphosphate diglyceride) will also ...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1971
ISSN: 0002-1369
DOI: 10.1080/00021369.1971.10859893